実績内容

実施している主な治療

クリニカルインディケーター（臨床の医療指標）

1)股関節脱臼における保存的治療の整復率

Rb：リーメンビューゲル装具   OHT：オーバーヘッド牽引法 （　）は股関節数

2)手術部位感染の発生率

※創外固定用ピンの遅発性感染を除く （　）は手術件数

誌上発表

• Activated FGFR3 suppresses bone regeneration and bone mineralization in an ovariectomized mouse model. Kawashima I, Matsushita M, Mishima K, Kamiya Y, Osawa Y, Ohkawara B, Ohno K, Kitoh H, Imagama S. BMC Musculoskelet Disord 24:1:200 (2023)
• Guided growth for coronal lower limb deformities in skeletal dysplasia. Kitoh H, Kamiya Y, Mishima K, Matsushita M, Kaneko H, Kitamura A, Sawamura K, Matsuyama S. J Pediatr Orthop B 32:2:157-164 (2023)
• Appropriate surgical timing of Salter innominate osteotomy for residual acetabular dysplasia in children. Sawamura K, Kitoh H, Kaneko H, Kitamura A, Hattori T. J Pediatr Orthop 42:10:e971-e975 (2022)
• Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice. Kato D, Matsushita M, Takegami Y, Mishima K, Kamiya N, Osawa Y, Imagama S, Kitoh H. Calcif Tissue Int 111:6:622-633 (2022)
• Changes of the lower limb deformity in children with FGF23-related hypophosphatemic rickets treated with Burosumab: a single-center prospective study. Sawamura K, Hamajima T, Izawa M, Kaneko H, Kitamura A, Kitoh H. J Pediatr Orthop B Online ahead of print (2022)
• こどもの下肢（膝関節とその周囲）の痛みの鑑別診断. 金子浩史. MB オルソペディクス 35:12:21-28 (2022)
• Efficacy of soluble lansoprazole-impregnated beta-tricalcium phosphate for bone regeneration. Mishima K, Okabe YT, Mizuno M, Ohno K, Kitoh H, Imagama S. Sci Rep 12:1:20550 (2022)
• Meclozine ameliorates bone mineralization and growth plate structure in a mouse model of X‑linked hypophosphatemia. Kamiya Y, Matsushita M, Mishima K, Ohkawara B, Michigami T, Imagama S, Ohno K, Kitoh H. Exp Ther Med 25:1:39 (2022)
• アスホターゼアルファによる酵素補充療法を併用して大腿骨延長を行った低ホスファターゼ症の1例. 松山沙織、鬼頭浩史、金子浩史、北村暁子、澤村健太. 日本整形外科学会雑誌 96:11:1050-1052 (2022)
• FGF23関連低リン血症性くる病患者の下肢変形に対するブロスマブの治療効果. 澤村健太、鬼頭浩史、金子浩史、北村暁子、松山沙織. 日本整形外科学会雑誌 96:11:1042-1046 (2022)
• Two children with hypophosphatasia with a heterozygous c.1559delT variant in the ALPL gene, the most common variant in Japanese populations. Kitoh H, Izawa M, Kaneko H, Kitamura A, Matsuyama S, Kato K, Ogi T. Bone Rep 17:101626 (2022)
• Perthes病に対する手術治療－骨盤骨切り術. 金子浩史. 整形・災害外科 65:10:1301-1306 (2022)
• Prognostic factors for mobility in children with osteogenesis imperfecta. Sawamura K, Kitoh H, Kaneko H, Kitamura A, Hattori T. Medicine (Baltimore) 101:36:e30521 (2022)
• 発育性股関節形成不全. 北村暁子. 整形外科看護 27:8:792-795 (2022)
• 栄養不足による骨代謝障害. 澤村健太、鬼頭浩史. 臨床整形外科 57:5:702-708 (2022)
• DDHに対する牽引療法の実際と臨床成績. 金子浩史. 関節外科 41:4:387-393 (2022)
• Predictive ability of inflammatory markers and laboratory parameters in Legg-Calvé-Perthes disease: A single-center retrospective comparative study. Mishima K, Kamiya Y, Matsushita M, Imagama S, Kitoh H. Medicine (Baltimore) 101:11:e29061 (2022)
• Meclozine attenuates the MARK pathway in mammalian chondrocytes and ameliorates FGF2-induced bone hyperossification in larval zebrafish. Takemoto G, Matsushita M, Okamoto T, Ito T, Matsuura Y, Takashima C, Chen-Yoshikawa TF, Ebi H, Imagama S, Kitoh H, Ohno K, Hosono Y. Front Cell Dev Biol 9:694018 (2022)
• Disease-specific complications and multidisciplinary interventions in achondroplasia. Kitoh H, Matsushita M, Mishima K, Kamiya Y, Sawamura K. J Bone Miner Metab 40：2：189-195 (2022)
• Inconvenience and adaptation in Japanese adult achondroplasia and hypochondroplasia: A cross-sectional study. Ajimi A, Matsushita M, Mishima K, Haga N, Fujiwara S, Ozono K, Kubota T, Kitaoka T, Imagama S, Kitoh H. Clin Pediatr Endocrinol 31：1：18-24 (2022)
• 骨形成不全症患者の移動能力についての検討. 澤村健太、鬼頭浩史、金子浩史、北村暁子、服部義. 日本整形外科学会雑誌 95：11：1038-1040 (2021)
• 低ホスファターゼ症. 鬼頭浩史. 整形・災害外科 64：9：1055-1061 (2021)
• Docking phenomenon and subsequent acetabular development after gradual reduction using overhead traction for developmental dysplasia of the hip over six months of age. Kaneko H, Kitoh H, Kitamura A, Sawamura K, Hattori T. J Child Orthop 15：6：554-563 (2021)
• Asfotase alfa has a limited effect in improving the bowed limbs in perinatal benign hypophosphatasia: A case report. Matsushita M, Mishima K, Nagata T, Kamiya Y, Imagama S, Kitoh H. Clin Pediatr Endocrinol 30：1：53-56 (2021)
• 低ホスファターゼ症に対する酵素補充療法. 鬼頭浩史. 整形・災害外科 64：1：93-97 (2021)
• Lower limb pain following allogeneic hematological stem cell transplantation in Japanese children. Mishima K, Kitoh H, Matsushita M, Nagata T, Nishida Y, Takahashi Y, Ishiguro N. J Orthop Sci  25：4：682-687 (2020)
• Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia. Kitoh H, Matsushita M, Mishima K, Nagata T, Kamiya Y, Ueda K, Kuwatsuka Y, Morikawa H, Nakai Y, Ishiguro N. PLoS One 15：4：e0229639 (2020)
• A novel NPR2 mutation (p.Arg388Gln) in a patient with Acromesomelic Dysplasia, type Maroteaux. Amano N, Kitoh H, Narumi S, Nishimura G, Hasegawa T. Clin Pediatr Endocrinol 29：3：99-103 (2020)
• A retrospective comparative study of corrective osteotomy for tibial deformities with the multiaxial correction fixator and the circular fixator. Matsushita M, Kitoh H, Mishima K, Nagata T, Kamiya Y, Kaneko H, Hattori T, Ishiguro N. J Clin Orthop Trauma  11(Suppl 4)：S621-S625 (2020)
• Effect of periosteal reaction on longitudinal bone growth in a mouse model of achondroplasia. Kaneko S, Matsushita M, Mishima K, Takegami Y, Imagama S, Kitoh H. Bone Reports 13：100708 (2020)
• Clinical aspects and current therapeutic approaches for FOP. Kitoh H. Biomedicines 8：9：325 (2020)
• Legg-Calve-Perthes disease in a patient with Bardet-Biedl syndrome -A case report of a novel MKKS/BBS6 mutation. Mishima K, Mizuno S, Matsushita M, Nagata T, Kamiya Y, Kitoh H. Clin Case Rep 8：12：3110-3115 (2020)
• Comparison of surgical and nonsurgical containment methods for patients with Legg-Calve-Perthes disease of the onset ages between 6.0 and 8.0 years: Salter osteotomy versus a non-weight-bearing hip flexion-abduction brace. Kaneko H, Kitoh H, Mishima K, Matsushita M, Hattori T, Noritake K, Ishiguro N, Yoshihashi Y. J Pediatr Orthop B 29：6：542-549 (2020)
• Response to: Citlak A. Surgical and nonsurgical containment methods for patients with Legg-Calve-Perthes disease of the onset ages between 6.0 and 8.0 years provided similar congruency of the hip joint. Kaneko H, Kitoh H. J Pediatr Orthop B 29：6：618-619 (2020)
• Gradual reduction using overhead traction for developmental dysplasia of the hip after walking age: a 30-year retrospective study. Kaneko H, Kitoh H, Iwata K, Mishima K, Matsushita M, Ishiguro N, Hattori T. Int J Pediatr Orthop 6：2：12-17 (2020)
• Sagittal plane deformity after temporary epiphysiodesis of the distal femur for correcting limb length discrepancy. Furuhashi H, Kaneko H, Iwata K, Hattori T. J Orthop Sci.  25：3：472-476 (2020)
• 骨硬化性疾患群に対する全国調査結果. 澤村健太、金子浩史、岩田浩志、北村暁子、鬼頭浩史、服部義. 日本整形外科学会雑誌 94：11：1071-1073 (2020)
• 乳児股関節脱臼診断遅延の現状と「推奨項目」によるスクリーニングの有用性. 澤村健太、金子浩史、岩田浩志、北村暁子、鬼頭浩史、服部義. 日本小児整形外科学会雑誌 29：2：226-228 (2020)
• Neglected Unstable Slipped Capital Femoral Epiphysis: A Case Report. Sawamura K, Mishima K, Matsushita M, Kamiya Y, Kitoh H. Acta Scientific Orthopaedics 3：12：87-90 (2020)
• Fibrodysplasia ossificans progressiva: Review and research activities in Japan. Haga N, Nakashima Y, Kitoh H, Kamizono J, Katagiri T, Saijo H, Tsuakamoto S, Shinoda Y, Sawada R, Nakahara Y. Pediatr Int 62：1：3-13 (2020)
• Impact of fracture characteristics and disease-specific complications on health-related quality of life in osteogenesis imperfecta. Matsushita M, Mishima K, Yamashita S, Haga N, Fujiwara S, Ozono K, Kubota T, Kitaoka T, Ishiguro N, Kitoh H. J Bone Miner Metab 38：1：109-116 (2020)
• Severe achondroplasia due to de novo variants in the transmembrane domain of FGFR3 on the same allele: A case report. Nagata T, Matsushita M, Mishima K, Kamiya Y, Kato K, Toyama M, Ogi T, Ishiguro N, Kitoh H. Mol Genet Genomic Med 8：3：e1148 (2020)