実績内容
| 2021年度 | 2022年度 | 2023年度 | |
|---|---|---|---|
| 外来延べ患者数 | 6,848 | 6,524 | 6,203 |
| 外来新患数 | 1,044 | 896 | 954 |
| 入院延べ患者数 | 4,020 | 3,474 | 3,506 |
実施している主な治療
| 【保存治療】 | 2021年度 | 2022年度 | 2023年度 |
|---|---|---|---|
| 乳幼児股関節脱臼に対するオーバーヘッド牽引法 | 2 | 5 | 3 |
| 環軸椎回旋位固定に対する入院牽引療法 | 3 | 1 | 1 |
| 麻痺性尖足、上下肢痙縮に対するボトックス注射 | 16 | 27 | 22 |
| 【手術治療】 | 2021年度 | 2022年度 | 2023年度 |
|---|---|---|---|
| 股関節疾患（股関節脱臼、ペルテス病など） | 22 | 24 | 11 |
| 足部疾患（内反足、多合趾症、麻痺性変形など） | 45 | 39 | 41 |
| 上肢疾患（母指多指症、橈尺骨癒合症など） | 6 | 8 | 11 |
| 下肢疾患（脚長差、O脚、X脚など） | 54 | 40 | 41 |
| 脊椎疾患（斜頚、脊柱変形など） | 9 | 8 | 2 |
| 腫瘍性疾患 | 2 | 3 | 8 |
| 炎症性疾患（感染など） | 3 | 0 | 0 |
| 外傷 | 4 | 5 | 2 |
| その他（抜釘など） | 71 | 70 | 77 |
| 合計 | 216 | 197 | 193 |
クリニカルインディケーター
1. 股関節脱臼における保存的治療の整復率
| 【乳幼児股関節脱臼】 | 2021年度 | 2022年度 | 2023年度 |
|---|---|---|---|
| Rb 脱臼整復率 | 71%（5/7） | 75% （9/12） | 100% （1/1） |
| OHT 脱臼整復率 | 100％（2/2） | 100% （4/4） | 100％（2/2） |
| 【先天異常を伴う股関節脱臼】 | 2020年度 | 2021年度 | 2022年度 |
|---|---|---|---|
| Rb 脱臼整復率 | – | – | – |
| OHT 脱臼整復率 | – | 0% （0/1） | 100% （1/1） |
2. 手術部位感染の発生率
| 2021年度 | 2022年度 | 2023年度 | |
| 感染発生率 | 0%（0/216） | 0% （0/197） | 1% （2/193） |
|---|
誌上発表
Severe achondroplasia due to two de novo variants in the transmembrane domain of FGFR3 on the same allele: A case report.
Nagata T, Matsushita M, Mishima K, Kamiya Y, Kato K, Toyama M, Ogi T, Ishiguro N, Kitoh H.
Mol Genet Genomic Med. 2020 Mar;8(3):e1148. doi: 10.1002/mgg3.1148. Epub 2020 Jan 23.
Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia.
Kitoh H, Matsushita M, Mishima K, Nagata T, Kamiya Y, Ueda K, Kuwatsuka Y, Morikawa H, Nakai Y, Ishiguro N.
PLoS One. 2020 Apr 13;15(4):e0229639. doi: 10.1371/journal.pone.0229639. eCollection 2020.
A retrospective comparative study of corrective osteotomy for tibial deformities with the multiaxial correction fixator and the circular fixator.
Matsushita M, Kitoh H, Mishima K, Nagata T, Kamiya Y, Kaneko H, Hattori T, Ishiguro N.
J Clin Orthop Trauma. 2020 Jul;11(Suppl 4):S621-S625. doi: 10.1016/j.jcot.2020.05.004. Epub 2020 May 15
Lower limb pain following allogeneic hematopoietic stem cell transplantation in Japanese children.
Mishima K, Kitoh H, Matsushita M, Nagata T, Kamiya Y, Takahashi Y, Ishiguro N.
J Orthop Sci. 2020 Jul;25(4):682-687. doi: 10.1016/j.jos.2019.07.007. Epub 2019 Jul 31.
Legg-Calvé-Perthes disease in a patient with Bardet-Biedl syndrome: A case report of a novel MKKS/BBS6 mutation.
Mishima K, Fujita A, Mizuno S, Matsushita M, Nagata T, Kamiya Y, Miyake N, Matsumoto N, Imagama S, Kitoh H.
Clin Case Rep. 2020 Sep 21;8(12):3110-3115. doi: 10.1002/ccr3.3357. eCollection 2020 Dec.
Comparison of surgical and nonsurgical containment methods for patients with Legg-Calve-Perthes disease of the onset ages between 6.0 and 8.0 years: Salter osteotomy versus a non-weight-bearing hip flexion-abduction brace.
Kaneko H, Kitoh H, Mishima K, Matsushita M, Hattori T, Noritake K, Ishiguro N, Yoshihashi Y.
J Pediatr Orthop B. 2020 Nov;29(6):542-549. doi: 10.1097/BPB.0000000000000710.
Asfotase alfa has a limited effect in improving the bowed limbs in perinatal benign hypophosphatasia: A case report.
Matsushita M, Mishima K, Nagata T, Kamiya Y, Imagama S, Kitoh H.
Clin Pediatr Endocrinol. 2021;30(1):53-56. doi: 10.1297/cpe.30.53. Epub 2021 Jan 5.
Docking phenomenon and subsequent acetabular development after gradual reduction using overhead traction for developmental dysplasia of the hip over six months of age.
Kaneko H, Kitoh H, Kitamura A, Sawamura K, Hattori T.
J Child Orthop. 2021 Dec 1;15(6):554-563. doi: 10.1302/1863-2548.15.210143.
Health-related quality of life in adult patients with multiple epiphyseal dysplasia and spondyloepiphyseal dysplasia.
Matsushita M, Mishima K, Kamiya Y, Haga N, Fujiwara S, Ozono K, Kubota T, Kitaoka T, Imagama S, Kitoh H.
Prog Rehabil Med. 2021 Dec 7;6:20210048. doi: 10.2490/prm.20210048. eCollection 2021.
Meclozine attenuates the MARK pathway in mammalian chondrocytes and ameliorates FGF2-induced bone hyperossification in larval zebrafish.
Takemoto G, Matsushita M, Okamoto T, Ito T, Matsuura Y, Takashima C, Chen-Yoshikawa TF, Ebi H, Imagama S, Kitoh H, Ohno K, Hosono Y.
Front Cell Dev Biol. 2022 Jan 18:9:694018. doi: 10.3389/fcell.2021.694018. eCollection 2021.
Disease-specific complications and multidisciplinary interventions in achondroplasia.
Kitoh H, Matsushita M, Mishima K, Kamiya Y, Sawamura K.
J Bone Miner Metab. 2022 Mar;40(2):189-195. doi: 10.1007/s00774-021-01298-z. Epub 2022 Jan 14.
Predictive ability of inflammatory markers and laboratory parameters in Legg-Calvé-Perthes disease: A single-center retrospective comparative study.
Mishima K, Kamiya Y, Matsushita M, Imagama S, Kitoh H.
Medicine (Baltimore). 2022 Mar 18;101(11):e29061. doi: 10.1097/MD.0000000000029061.
Bypass of epiphyseal fragmentation following early Salter innominate osteotomy and its clinical relevance in Legg-Calvé-Perthes disease.
Mishima K, Kamiya Y, Matsushita M, Imagama S, Kitoh H.
J Pediatr Orthop. 2022 May-Jun 01;42(5):239-245. doi: 10.1097/BPO.0000000000002089.
A cross-sectional nationwide survey of osteosclerotic skeletal dysplasias in Japan.
Sawamura K, Mishima K, Matsushita M, Kamiya Y, Kitoh H.
J Orthop Sci. 2022 Sep;27(5):1139-1142. doi: 10.1016/j.jos.2021.05.012. Epub 2021 Jul 15.
Prognostic factors for mobility in children with osteogenesis imperfecta.
Sawamura K, Kitoh H, Kaneko H, Kitamura A, Hattori T.
Medicine (Baltimore). 2022 Sep 9;101(36):e30521. doi: 10.1097/MD.0000000000030521.
Two children with hypophosphatasia with a heterozygous c.1559delT variant in the ALPL gene, the most common variant in Japanese populations.
Kitoh H, Izawa M, Kaneko H, Kitamura A, Matsuyama S, Kato K, Ogi T.
Bone Rep. 2022 Oct 4:17:101626. doi: 10.1016/j.bonr.2022.101626. eCollection 2022 Dec.
Efficacy of soluble lansoprazole-impregnated beta-tricalcium phosphate for bone regeneration.
Mishima K, Okabe YT, Mizuno M, Ohno K, Kitoh H, Imagama S.
Sci Rep. 2022 Nov 29;12(1):20550. doi: 10.1038/s41598-022-25184-4.
Meclozine ameliorates bone mineralization and growth plate structure in a mouse model of X‑linked hypophosphatemia.
Kamiya Y, Matsushita M, Mishima K, Ohkawara B, Michigami T, Imagama S, Ohno K, Kitoh H.
Exp Ther Med. 2022 Nov 30;25(1):39. doi: 10.3892/etm.2022.11738. eCollection 2023 Jan.
Appropriate surgical timing of Salter innominate osteotomy for residual acetabular dysplasia in children.
Sawamura K, Kitoh H, Kaneko H, Kitamura A, Hattori T.
J Pediatr Orthop. 2022 Nov-Dec;42(10):e971-e975. doi: 10.1097/BPO.0000000000002258. Epub 2022 Aug 30.
Gain-of-function of FGFR3 accelerates bone repair following ischemic osteonecrosis in juvenile mice.
Kato D, Matsushita M, Takegami Y, Mishima K, Kamiya N, Osawa Y, Imagama S, Kitoh H.
Calcif Tissue Int. 2022 Dec;111(6):622-633. doi: 10.1007/s00223-022-01019-2. Epub 2022 Sep 7.
Inconvenience and adaptation in Japanese adult achondroplasia and hypochondroplasia: A cross-sectional study.
Ajimi A, Matsushita M, Mishima K, Haga N, Fujiwara S, Ozono K, Kubota T, Kitaoka T, Imagama S, Kitoh H.
Clin Pediatr Endocrinol. 2022;31(1):18-24. doi: 10.1297/cpe.2021-0043. Epub 2021 Nov 1.
Scurvy as a differential diagnosis of diffuse musculoskeletal pain in children: Two case reports.
Kitoh H, Sawamura K, Kaneko H, Kitamura A, Matsuyama S.
JOS Case Rep. 2022;1:11-14.
Acute osteomyelitis of the patella due to Pseudomonas aeruginosa in an immunocompetent child: A case report.
Kamiya Y, Mishima K, Tanaka T, Sawamura K, Matsushita M, Imagama S.
Medicine (Baltimore). 2023 Feb 17;102(7):e33012. doi: 10.1097/MD.0000000000033012.
Activated FGFR3 suppresses bone regeneration and bone mineralization in an ovariectomized mouse model.
Kawashima I, Matsushita M, Mishima K, Kamiya Y, Osawa Y, Ohkawara B, Ohno K, Kitoh H, Imagama S.
BMC Musculoskelet Disord. 2023 Mar 16;24(1):200. doi: 10.1186/s12891-023-06318-9.
Guided growth for coronal lower limb deformities in skeletal dysplasia.
Kitoh H, Kamiya Y, Mishima K, Matsushita M, Kaneko H, Kitamura A, Sawamura K, Matsuyama S.
J Pediatr Orthop B. 2023 Mar 1;32(2):157-164. doi: 10.1097/BPB.0000000000000965. Epub 2022 Feb 21.
Prognostic value of bone resorption pattern in the anterior portion of the femoral head in Legg-Calvé-Perthes disease.
Mishima K, Kamiya Y, Matsushita M, Imagama S.
J Child Orthop. 2023 Apr 7;17(3):197-204. doi: 10.1177/18632521231164985. eCollection 2023 Jun.
Phase 1b study on the repurposing of meclizine hydrochloride for children with achondroplasia.
Matsushita M, Kitoh H, Mishima K, Kamiya Y, Kato D, Takemoto G, Sawamura K, Ueno S, Yasuhiro N, Nishida K, Imagama S.
PLoS One. 2023 Jul 10;18(7):e0283425. doi: 10.1371/journal.pone.0283425. eCollection 2023.
Femoral lengthening with enzyme replacement therapy in an adolescent patient with prenatal benign hypophosphatasia: A case report.
Kitoh H, Kaneko H, Kitamura A, Sawamura K.
J Orthop Sci. 2023 Nov;28(6):1487-1491. doi: 10.1016/j.jos.2021.07.010.
Changes of the lower limb deformity in children with FGF23-related hypophosphatemic rickets treated with Burosumab: A single-center prospective study.
Sawamura K, Hamajima T, Izawa M, Kaneko H, Kitamura A, Kitoh H.
J Pediatr Orthop B. 2024 Jan 1;33(1):90-96. doi: 10.1097/BPB.0000000000001054.
Long-term oral meclozine administration improves survival rate and spinal canal stenosis during postnatal growth in a mouse model of achondroplasia in both sexes.
Funahashi H, Matsushita M, Esaki R, Mishima K, Ohkawara B, Kamiya Y, Takegami Y, Ohno K, Kitoh H, Imagama S.
JBMR Plus. 2024 Feb 24;8(4):ziae018. doi: 10.1093/jbmrpl/ziae018. eCollection 2024 Apr.
Quality of life in adult patients with developmental dysplasia of the hip who were treated for hip dislocation during childhood.
Sawamura K, Kitoh H, Matsushita M, Mishima K, Kamiya Y, Imagama S.
J Pediatr Orthop B. 2024 Feb 26. doi: 10.1097/BPB.0000000000001173.
Gradual reduction using overhead traction for late-detected developmental dysplasia of the hip: A report of three cases diagnosed among children over four years old.
Mishima K, Kamiya Y, Sawamura K, Matsushita M, Imagama S.
Cureus. 2024 Jul 4;16(7):e63833. doi: 10.7759/cureus.63833. eCollection 2024 Jul.
Improvement of fibrous dysplasia after burosumab therapy in a pediatric patient with McCune-Albright syndrome: A case report.
Sawamura K, Hamajima T, Kitoh H.
JBJS Case Connect. 2024 Sep 20;14(3). doi: 10.2106/JBJS.CC.24.00279.
International expert opinion on the considerations for combining vosoritide and limb surgery: A modified delphi study.
Boero S, Vodopiutz J, Maghnie M, de Bergua JM, Ginebreda I, Kitoh H, Langendörfer M, Leiva-Gea A, Malone J, McClure P, Mindler GT, Popkov D, Rodl R, Rosselli P, Verdoni F, Vilenskii V, Huser AJ.
Orphanet J Rare Dis. 2024 Sep 17;19(1):347. doi: 10.1186/s13023-024-03236-4.
Vosoritide therapy in children with achondroplasia under 5 years of age.
Kitoh H.
Transl Pediatr. 2024 Sep 30;13(9):1517-1520. doi: 10.21037/tp-24-186.
乳児股関節脱臼診断遅延の現状と「推奨項目」によるスクリーニングの有用性.
澤村 健太, 鬼頭 浩史, 金子 浩史, 岩田 浩志, 北村 暁子, 服部 義.
日本小児整形外科学会雑誌 2020;29(2):226-228.
進行性骨化性線維異形成症に関する臨床研究.
芳賀 信彦, 中島 康晴, 鬼頭 浩史, 片桐 岳信, 神薗 淳司, 西條 英人.
脊椎脊髄ジャーナル 2020;33(2):145-150.
新しい医療技術 低ホスファターゼ症に対する酵素補充療法.
鬼頭 浩史.
整形・災害外科 2021;64(1):93-97.
低ホスファターゼ症.
鬼頭 浩史.
整形・災害外科 2021;64(9):1055-1061.
DDHに対する牽引療法の実際と臨床成績.
金子 浩史.
関節外科 2022;41(4):387-393.
発育性股関節形成不全.
北村 暁子.
整形外科看護 2022;27(8):792-795.
Perthes病に対する手術治療－骨盤骨切り術．
金子 浩史.
整形・災害外科 2022;65(10):1301-1306.
こどもの下肢（膝関節とその周囲）の痛みの鑑別診断．
金子 浩史.
MB オルソペディクス 2022;35(12):21-28.
白血球(顆粒球)の異常(悪性腫瘍を除く) 単球の異常 単球減少症 大理石骨病.
鬼頭 浩史.
日本臨床 2023;別冊(血液症候群II):182-184
発育性股関節形成不全に対するSalter骨盤骨切り術の持続的効果．
金子 浩史, 北村 暁子, 松山 沙織, 今井 澄, 鬼頭 浩史.
日本小児整形外科学会雑誌 2023;32(1):1-5.
8歳以上のペルテス病に対するSalter骨盤骨切り術．
金子 浩史, 北村 暁子, 松山 沙織, 今井 澄, 鬼頭 浩史.
日本小児整形外科学会雑誌 2024;33(1):18-22.
指定難病最前線 TRPV4異常症.
鬼頭 浩史.
新薬と臨床 2024;73(9):902-905
